This 8-lecture course aims to provide crucial insights into the management of molecular biology, emphasizing an understanding of how diseases induce modifications, specifically disregulation, in the gene expression program. The impact of this phenomenon is aptly demonstrated in cancer cells, where tumor growth results in a unique form of transcription addiction Furthermore, delving into the intricacies of gene expression regulation holds the potential to identify pathological markers and discern possible targets for chemotherapy or immunotherapy. Active participation from students is integral to this course, involving the delivery of presentations on assigned topics, marked by an asterisk and limited to a concise 15 minutes. Additionally, two specific topics will be presented by two Principal Investigators (PIs) with whom I have collaborated.